General Study Information

This study compares electroconvulsive therapy (ECT) and the medication ketamine to see which works best for adults with treatment-resistant depression. ECT, sometimes called shock therapy, is an effective treatment for adults with treatment-resistant depression. But people may feel ashamed about getting ECT or may not like its side effects, such as memory problems. They may also dislike receiving anesthesia to become unconscious to get ECT or suffering memory loss from the treatment. Ketamine has no effects on memory and is given when a person is awake, but it may have other side effects and is not a standard treatment for depression.